Involvement of non‐melanocytic skin cells in vitiligo

Evaluation of relationship between skin involvement and hearing loss in patients with vitiligo

Vitiligo is a common acquired depigmented disorder of the skin that can lead to social negative outcomes, including reduced quality of life. Melanocytes disorder can also occur within other organs, such as ear. Different areas of the inner ear, such as the cochlear duct and vestibular system, have melanocytes. This study was conducted with the aim of evaluating the relationship between skin inv...

Langerhans Cells in Skin Lesions of Leprosy

Background: Langerhans cells are important in the pathogenesis of leprosy.  A recent study reported that these cells were almost absent in the epidermis overlying lepromatous lesions. Objective: To investigate a possible relationship between the number of Langerhans cells and the histopathologic spectrum of lesions in patients with leprosy. Methods: An immunohistochemical staining for S100 prot...

Update on skin repigmentation therapies in vitiligo.

Treatment for vitiligo is difficult and prolonged. Nevertheless, at present considerable knowledge accumulated during several decades on the pathogenic mechanisms, revealed important clues for designing new strategies to improve vitiligo depigmentation. With available medical therapies, high repigmentation percentages mostly on facial and neck lesions are achieved, although they are less effect...

Differentiating intratumoral melanocytes from Langerhans cells in nonmelanocytic pigmented skin tumors in vivo by label-free third-harmonic generation microscopy.

Morphology and distribution of melanocytes are critical imaging information for the diagnosis of melanocytic lesions. However, how to image intratumoral melanocytes noninvasively in pigmented skin tumors is seldom investigated. Third-harmonic generation (THG) is shown to be enhanced by melanin, whereas high accuracy has been demonstrated using THG microscopy for in vivo differential diagnosis o...

The Psychosocial Aspects of Vitiligo: A Focus on Stress Involvement in Children with Vitiligo